Cancer is a major healthcare burden across the world and impacts not only the people diagnosed with various cancers but also their families, carers, and healthcare systems. With advances in the diagnosis and treatment, more people are diagnosed early and receive treatments for a disease where few treatments options were previously available. As a result, the survival of patients with cancer has steadily improved and, in most cases, patients who are not cured may receive multiple lines of treatment, often with financial consequences for the patients, insurers and healthcare systems. Although many books exist that address economic evaluation, Economic Evaluation of Cancer Drugs using Clinical Trial and Real World Data is the first unified text that specifically addresses the economic evaluation of cancer drugs. The authors discuss how to perform cost-effectiveness analyses while emphasising the strategic importance of designing cost-effectiveness into cancer trials and building robust economic evaluation models that have a higher chance of reimbursement if truly cost-effective. They cover the use of real-world data using cancer registries and discuss how such data can support or complement clinical trials with limited follow up. Lessons learned from failed reimbursement attempts, factors predictive of successful reimbursement and the different payer requirements across major countries including US, Australia, Canada, UK, Germany, France and Italy are also discussed. The book includes many detailed practical examples, case studies and thought-provoking exercises for use in classroom and seminar discussions. Iftekhar Khan is a medical statistician and health economist and a lead statistician at Oxford Unviersity's Center for Statistics in Medicine. Professor Khan is also a Senior Research Fellow in Health Economics at University of Warwick and is a Senior Statistical Assessor within the Licensing Division of the UK Medicine and Health Regulation Agency. Ralph Crott is a former professor in Pharmacoeconomics at the University of Montreal in Quebec, Canada and former head of the EORTC Health Economics Unit and former senior health economist at the Belgian HTA organization. Zahid Bashir has over twelve years experience working in the pharmaceutical industry in medical affairs and oncology drug development where he is involved in the design and execution of oncology clinical trials and development of reimbursement dossiers for HTA submission.

This book considers the challenges of building disaster resilience in South Asia - a region that frequently experiences some of the most severe and devastating impacts of disasters. Despite significant work to assist affected communities, many smaller South Asian countries remain particularly vulnerable in terms of fostering disaster resilience. Drawing on examples from Bangladesh, Bhutan, Maldives, Nepal and Sri Lanka, the book offers rich insights and narratives on disaster resilience policy and practice. It considers the possibilities for advancing community resilience and capacity building through an exploration of different aspects of governance and policy. Given the diversity of these countries and recent disasters, a variety of perspectives are considered: institutional and policy frameworks, risk management governance, recovery operations, building codes, and policy and media discourse. The book offers a collective understanding of practice, which can offer global lessons to a world increasingly beset by disasters and with uncertain environmental futures. This book will be a valuable resource for scholars, practitioners and students in the fields of disaster risk reduction and management, climate change adaptation, public policy and sustainable development.

This handbook examines Pakistan's 70-year history from a number of different perspectives. When Pakistan was born, it did not have a capital, a functioning government or a central bank. The country lacked a skilled workforce. While the state was in the process of being established, eight million Muslim refugees arrived from India, who had to be absorbed into a population of 24 million people. However, within 15 years, Pakistan was the fastest growing and transforming economy in the developing world, although the political evolution of the country during this period was not equally successful. Pakistan has vast agricultural and human resources, and its location promises trade, investment and other opportunities. Chapters in the volume, written by experts in the field, examine government and politics, economics, foreign policy and environmental issues, as well as social aspects of Pakistan's development, including the media, technology, gender and education. Shahid Javed Burki is an economist who has been a member of the faculty at Harvard University, USA, and Chief Economist, Planning and Development Department, Government of the Punjab. He has also served as Minister of Finance in the Government of Pakistan, and has written a number of books, and journal and newspaper articles. He joined the World Bank in 1974 as a senior economist and went on to serve in several senior positions. He was the (first) Director of the China Department (1987-94) and served as the Regional Vice-President for Latin America and the Caribbean during 1994-99. He is currently the Chair of the Board of Directors of the Shahid Javed Burki Institute of Public Policy at NetSol (BIPP) in Lahore. Iftekhar Ahmed Chowdhury is a career Bangladeshi diplomat and former Minister of Foreign Affairs in the Government of Bangladesh (2007-08). He has a PhD in international relations from the Australian National University, Canberra. He began his career as a member of the civil service of Pakistan in 1969. Dr Chowdhury has held senior diplomatic positions in the course of his career, including as Permanent Representative of Bangladesh to the United Nations in New York (2001-07) and in Geneva (1996-2001), and was ambassador to Qatar, Chile, Peru and the Vatican. He is currently a visiting senior research fellow at the Institute of South Asian Studies, National University of Singapore. Asad Ejaz Butt is the Director of the Burki Institute of Public Policy, Lahore, Pakistan.

Cancer is a major healthcare burden across the world and impacts not only the people diagnosed with various cancers but also their families, carers, and healthcare systems. With advances in the diagnosis and treatment, more people are diagnosed early and receive treatments for a disease where few treatments options were previously available. As a result, the survival of patients with cancer has steadily improved and, in most cases, patients who are not cured may receive multiple lines of treatment, often with financial consequences for the patients, insurers and healthcare systems. Although many books exist that address economic evaluation, Economic Evaluation of Cancer Drugs using Clinical Trial and Real World Data is the first unified text that specifically addresses the economic evaluation of cancer drugs. The authors discuss how to perform cost-effectiveness analyses while emphasising the strategic importance of designing cost-effectiveness into cancer trials and building robust economic evaluation models that have a higher chance of reimbursement if truly cost-effective. They cover the use of real-world data using cancer registries and discuss how such data can support or complement clinical trials with limited follow up. Lessons learned from failed reimbursement attempts, factors predictive of successful reimbursement and the different payer requirements across major countries including US, Australia, Canada, UK, Germany, France and Italy are also discussed. The book includes many detailed practical examples, case studies and thought-provoking exercises for use in classroom and seminar discussions. Iftekhar Khan is a medical statistician and health economist and a lead statistician at Oxford Unviersity's Center for Statistics in Medicine. Professor Khan is also a Senior Research Fellow in Health Economics at University of Warwick and is a Senior Statistical Assessor within the Licensing Division of the UK Medicine and Health Regulation Agency. Ralph Crott is a former professor in Pharmacoeconomics at the University of Montreal in Quebec, Canada and former head of the EORTC Health Economics Unit and former senior health economist at the Belgian HTA organization. Zahid Bashir has over twelve years experience working in the pharmaceutical industry in medical affairs and oncology drug development where he is involved in the design and execution of oncology clinical trials and development of reimbursement dossiers for HTA submission.

This book considers the challenges of building disaster resilience in South Asia - a region that frequently experiences some of the most severe and devastating impacts of disasters. Despite significant work to assist affected communities, many smaller South Asian countries remain particularly vulnerable in terms of fostering disaster resilience. Drawing on examples from Bangladesh, Bhutan, Maldives, Nepal and Sri Lanka, the book offers rich insights and narratives on disaster resilience policy and practice. It considers the possibilities for advancing community resilience and capacity building through an exploration of different aspects of governance and policy. Given the diversity of these countries and recent disasters, a variety of perspectives are considered: institutional and policy frameworks, risk management governance, recovery operations, building codes, and policy and media discourse. The book offers a collective understanding of practice, which can offer global lessons to a world increasingly beset by disasters and with uncertain environmental futures. This book will be a valuable resource for scholars, practitioners and students in the fields of disaster risk reduction and management, climate change adaptation, public policy and sustainable development.

Community Engagement in Post-Disaster Recovery reflects a wide array of practical experiences in working with disaster-affected communities internationally. It demonstrates that widely held assumptions about the benefits of community consultation and engagement in disaster recovery work need to be examined more critically because poorly conceived and hastily implemented community engagement strategies have sometimes exacerbated divisions within affected communities and/or resulted in ineffective use of aid funding. It is equally demonstrated that well-crafted, creative and thoughtful programming is possible. The wide collection of case studies of practical experience from around the world is presented to help establish ways of working with communities experiencing great challenges. The book offers practical suggestions on how to give more substance to the rhetoric of community consultation and engagement in these areas of work. It suggests the need to work with a dynamic understanding of community formation that is particularly relevant when people experience unforeseen challenges and traumatic experiences. This title interrogates the concept of community through an extensive review of the literature and explores the ways of working with communities in transition and particularly in their recovery phases through an array of case studies in a range of socioeconomic and political contexts. Focused on the concept of community in post-disaster recovery solutions-an aspect which has received little critical interrogation in the literature-this book will be a valuable resource to students and scholars in disaster management as well as humanitarian agencies.

Community Engagement in Post-Disaster Recovery reflects a wide array of practical experiences in working with disaster-affected communities internationally. It demonstrates that widely held assumptions about the benefits of community consultation and engagement in disaster recovery work need to be examined more critically because poorly conceived and hastily implemented community engagement strategies have sometimes exacerbated divisions within affected communities and/or resulted in ineffective use of aid funding. It is equally demonstrated that well-crafted, creative and thoughtful programming is possible. The wide collection of case studies of practical experience from around the world is presented to help establish ways of working with communities experiencing great challenges. The book offers practical suggestions on how to give more substance to the rhetoric of community consultation and engagement in these areas of work. It suggests the need to work with a dynamic understanding of community formation that is particularly relevant when people experience unforeseen challenges and traumatic experiences. This title interrogates the concept of community through an extensive review of the literature and explores the ways of working with communities in transition and particularly in their recovery phases through an array of case studies in a range of socioeconomic and political contexts. Focused on the concept of community in post-disaster recovery solutions-an aspect which has received little critical interrogation in the literature-this book will be a valuable resource to students and scholars in disaster management as well as humanitarian agencies.

Economic evaluation has become an essential component of clinical trial design to show that new treatments and technologies offer value to payers in various healthcare systems. Although many books exist that address the theoretical or practical aspects of cost-effectiveness analysis, this book differentiates itself from the competition by detailing how to apply health economic evaluation techniques in a clinical trial context, from both academic and pharmaceutical/commercial perspectives. It also includes a special chapter for clinical trials in Cancer. Design & Analysis of Clinical Trials for Economic Evaluation & Reimbursement is not just about performing cost-effectiveness analyses. It also emphasizes the strategic importance of economic evaluation and offers guidance and advice on the complex factors at play before, during, and after an economic evaluation. Filled with detailed examples, the book bridges the gap between applications of economic evaluation in industry (mainly pharmaceutical) and what students may learn in university courses. It provides readers with access to SAS and STATA code. In addition, Windows-based software for sample size and value of information analysis is available free of charge-making it a valuable resource for students considering a career in this field or for those who simply wish to know more about applying economic evaluation techniques. The book includes coverage of trial design, case report form design, quality of life measures, sample sizes, submissions to regulatory authorities for reimbursement, Markov models, cohort models, and decision trees. Examples and case studies are provided at the end of each chapter. Presenting first-hand insights into how economic evaluations are performed from a drug development perspective, the book supplies readers with the foundation required to succeed in an environment where clinical trials and cost-effectiveness of new treatments are central. It also includes thought-provoking exercises for use in classroom and seminar discussions.

Through 12 case studies from Australia, Bangladesh, Haiti, Sri Lanka, Vietnam and the USA, this book focuses on the housing reconstruction process after an earthquake, tsunami, cyclone, flood or fire. Design of post-disaster housing is not simply replacing the destroyed house but, as these case studies highlight, a means to not only build a safer house but also a more resilient community; not to simply return to the same condition as before the disaster, but an opportunity for building back better. The book explores two main themes: Housing reconstruction is most successful when involving the users in the design and construction process Housing reconstruction is most effective when it is integrated with community infrastructure, services and the means to create real livelihoods. The case studies included in this book highlight work completed by different agencies and built environment professionals in diverse disaster-affected contexts. With a global acceleration of natural disasters, often linked to accelerating climate change, there is a critical demand for robust housing solutions for vulnerable communities. This book provides professionals, policy makers and community stakeholders working in the international development and disaster risk management sectors, with an evidence-based exploration of how to add real value through the design process in housing reconstruction. Herein then, the knowledge we need to build, an approach to improve our processes, a window to understanding the complex domain of post-disaster housing reconstruction.

Economic evaluation has become an essential component of clinical trial design to show that new treatments and technologies offer value to payers in various healthcare systems. Although many books exist that address the theoretical or practical aspects of cost-effectiveness analysis, this book differentiates itself from the competition by detailing how to apply health economic evaluation techniques in a clinical trial context, from both academic and pharmaceutical/commercial perspectives. It also includes a special chapter for clinical trials in Cancer. Design & Analysis of Clinical Trials for Economic Evaluation & Reimbursement is not just about performing cost-effectiveness analyses. It also emphasizes the strategic importance of economic evaluation and offers guidance and advice on the complex factors at play before, during, and after an economic evaluation. Filled with detailed examples, the book bridges the gap between applications of economic evaluation in industry (mainly pharmaceutical) and what students may learn in university courses. It provides readers with access to SAS and STATA code. In addition, Windows-based software for sample size and value of information analysis is available free of charge-making it a valuable resource for students considering a career in this field or for those who simply wish to know more about applying economic evaluation techniques. The book includes coverage of trial design, case report form design, quality of life measures, sample sizes, submissions to regulatory authorities for reimbursement, Markov models, cohort models, and decision trees. Examples and case studies are provided at the end of each chapter. Presenting first-hand insights into how economic evaluations are performed from a drug development perspective, the book supplies readers with the foundation required to succeed in an environment where clinical trials and cost-effectiveness of new treatments are central. It also includes thought-provoking exercises for use in classroom and seminar discussions.

This handbook examines Pakistan's 70-year history from a number of different perspectives. When Pakistan was born, it did not have a capital, a functioning government or a central bank. The country lacked a skilled workforce. While the state was in the process of being established, eight million Muslim refugees arrived from India, who had to be absorbed into a population of 24 million people. However, within 15 years, Pakistan was the fastest growing and transforming economy in the developing world, although the political evolution of the country during this period was not equally successful. Pakistan has vast agricultural and human resources, and its location promises trade, investment and other opportunities. Chapters in the volume, written by experts in the field, examine government and politics, economics, foreign policy and environmental issues, as well as social aspects of Pakistan's development, including the media, technology, gender and education. Shahid Javed Burki is an economist who has been a member of the faculty at Harvard University, USA, and Chief Economist, Planning and Development Department, Government of the Punjab. He has also served as Minister of Finance in the Government of Pakistan, and has written a number of books, and journal and newspaper articles. He joined the World Bank in 1974 as a senior economist and went on to serve in several senior positions. He was the (first) Director of the China Department (1987-94) and served as the Regional Vice-President for Latin America and the Caribbean during 1994-99. He is currently the Chair of the Board of Directors of the Shahid Javed Burki Institute of Public Policy at NetSol (BIPP) in Lahore. Iftekhar Ahmed Chowdhury is a career Bangladeshi diplomat and former Minister of Foreign Affairs in the Government of Bangladesh (2007-08). He has a PhD in international relations from the Australian National University, Canberra. He began his career as a member of the civil service of Pakistan in 1969. Dr Chowdhury has held senior diplomatic positions in the course of his career, including as Permanent Representative of Bangladesh to the United Nations in New York (2001-07) and in Geneva (1996-2001), and was ambassador to Qatar, Chile, Peru and the Vatican. He is currently a visiting senior research fellow at the Institute of South Asian Studies, National University of Singapore. Asad Ejaz Butt is the Director of the Burki Institute of Public Policy, Lahore, Pakistan.

This book includes selected papers presented at the international expert forum on "Mainstreaming Resilience and Disaster Risk Reduction in Education," held at the Asian Institute of Technology, Thailand on 1-2 December 2017. The journey towards disaster risk reduction and resilience requires the participation of a wide array of stakeholders ranging from academics to policymakers, to disaster managers. Given the multifaceted and interdependent nature of disasters, disaster risk reduction and resilience require a multidisciplinary problem-solving approach and evidence-based techniques from the natural, social, engineering, and other relevant sciences. Traditionally, hazard and disaster-related studies have been dominated by the engineering and social science fields. In this regard, the main purpose of this book is to capture the multidisciplinary and multisectoral nature of disaster risk reduction, and to gather existing data, research, conceptual work, and practical cases regarding risk reduction and its ties to sustainable development under a single "umbrella." Along with the sustainability aspect, the book also links disaster risk reduction with development, technology, governance, education, and climate change, and includes discussions on challenges, solutions, and best practices in the mainstreaming of disaster risk reduction.

Through 12 case studies from Australia, Bangladesh, Haiti, Sri Lanka, Vietnam and the USA, this book focuses on the housing reconstruction process after an earthquake, tsunami, cyclone, flood or fire. Design of post-disaster housing is not simply replacing the destroyed house but, as these case studies highlight, a means to not only build a safer house but also a more resilient community; not to simply return to the same condition as before the disaster, but an opportunity for building back better. The book explores two main themes: Housing reconstruction is most successful when involving the users in the design and construction process Housing reconstruction is most effective when it is integrated with community infrastructure, services and the means to create real livelihoods. The case studies included in this book highlight work completed by different agencies and built environment professionals in diverse disaster-affected contexts. With a global acceleration of natural disasters, often linked to accelerating climate change, there is a critical demand for robust housing solutions for vulnerable communities. This book provides professionals, policy makers and community stakeholders working in the international development and disaster risk management sectors, with an evidence-based exploration of how to add real value through the design process in housing reconstruction. Herein then, the knowledge we need to build, an approach to improve our processes, a window to understanding the complex domain of post-disaster housing reconstruction.

New venture founders and their sponsors seek to create economic value by finding and commercializing new and better ways of doing things. Their common goal, which also defines the purpose of the entrepreneurial process itself, requires a better grasp of the key elements that influence the choices involved in attempting to create economic value under highly uncertain conditions. It also requires a deeper understanding of the consequences of new venture investment as well as the various contextual factors that influence investment decisions and venture outcomes. When confronted with a particular decision making problem faced by entrepreneurs and new venture investors, academic scholars analyze how and why the problem in question is a special case of some theory or model which they know. In seeking to detect generalities and to make abstracted sense of observed realities, academics generally classify the problem in a way that is a natural consequence of the specific discipline- or field-based knowledge they possess (Davidsson, 2002). The explanations that academic researchers provide and the predictions they make are therefore likely to be framed in terms of the types of variables, theoretical perspectives, levels of analysis, and research methodologies with which they are familiar. In seeking to explore the intellectual underpinnings of new venture investment, we have gathered and organized a set of papers that provide scholarly analysis of the choices involved in new venture investment as well as the various contextual factors that influence investment outcomes. To insure a more robust and hopefully interesting scholarly treatment of such problems, we sought to include a variety of interdisciplinary and international perspectives that reflect a broad range of theoretical and empirical approaches.

This book includes selected papers presented at the international expert forum on "Mainstreaming Resilience and Disaster Risk Reduction in Education," held at the Asian Institute of Technology, Thailand on 1-2 December 2017. The journey towards disaster risk reduction and resilience requires the participation of a wide array of stakeholders ranging from academics to policymakers, to disaster managers. Given the multifaceted and interdependent nature of disasters, disaster risk reduction and resilience require a multidisciplinary problem-solving approach and evidence-based techniques from the natural, social, engineering, and other relevant sciences. Traditionally, hazard and disaster-related studies have been dominated by the engineering and social science fields. In this regard, the main purpose of this book is to capture the multidisciplinary and multisectoral nature of disaster risk reduction, and to gather existing data, research, conceptual work, and practical cases regarding risk reduction and its ties to sustainable development under a single "umbrella." Along with the sustainability aspect, the book also links disaster risk reduction with development, technology, governance, education, and climate change, and includes discussions on challenges, solutions, and best practices in the mainstreaming of disaster risk reduction.